PUBLICATIONS
Sep 13, 2019 | Clinical Trials, Publications
Abstract Background and Purpose Stroke is a leading cause of long-term disability. Limited treatment options exist for patients with chronic stroke and substantial functional deficits. The current study examined safety and preliminary efficacy estimates of intravenous…
New Stem Cell Therapy May Transform Heart Failure Treatment
Apr 18, 2018 | Clinical Trials, Publications, Subsidiaries
Washington, D.C., April 18, 2018 – Clinical trial planning is underway at MedStar Heart & Vascular Institute to determine whether a novel stem cell therapy will improve heart function for patients with heart failure. MedStar Heart, in partnership with CardioCell,…
Sep 13, 2017 | Publications
Background: We previously reported that functional recovery of rats with spinal cord contusions can occur after acute transplantation of neural stem cells distal to the site of injury. To investigate the effects of timing of administration of human neural stem cell…
Feb 23, 2017 | Publications
Abstract Rationale: Virtually all mesenchymal stem cell (MSC) studies assume therapeutic effects accrue from local myocardial effects of engrafted MSCs. Since few intravenously-administered MSCs engraft in the myocardium, studies have mainly utilized direct myocardial…
Feb 8, 2017 | Publications
Abstract Alzheimer’s disease is the most common form of dementia in the western world, however there is no cure available for this devastating neurodegenerative disorder. Despite clinical and experimental evidence implicating the intestinal microbiota in a number of…
Nov 16, 2016 | Publications
Potential benefits of mesenchymal stem cell (MSC) therapy in heart failure (HF) may be related to paracrine properties and systemic effects, including anti-inflammatory activities. If this hypothesis is valid, intravenous administration of MSCs should improve outcomes in HF, an entity in which excessive chronic inflammation may play a pivotal role.
Nov 9, 2016 | Publications
The impact of human adult ischemia-tolerant mesenchymal stem cells (hMSC) and factors (SCF) on cerebral amyloid-beta (Aβ) pathology was investigated in a mouse model of Alzheimer’s disease (AD).
Jul 7, 2016 | Publications
The dependences of spreading and differentiation of stem cells plated on hydrogel and silicone gel substrates on the rigidity and porosity of the substrates have recently been a subject of some controversy…
Jun 1, 2016 | Publications
The purpose of the study was to determine if the local or distal injection of neural stem cells can cause functional difference in recovery after chronic spinal cord injury.
May 13, 2016 | Publications
ABSTRACT Developing effective therapies for heart failure (HF) is challenging. Despite several clear successes in the development and delivery of pharmacotherapies for ambulatory patients with HF and reduced ejection fraction (HFrEF), efforts to modulate adverse…
Circulation Research – Development of Therapeutics for Heart Failure
Mar 15, 2016 | Publications
Abstract Compared with heart failure (HF) care 20 to 30 years ago, there has been tremendous advancement in therapy for ambulatory HF with reduced ejection fraction with the use of agents that block maladaptive neurohormonal pathways. However, during the past decade,…
Nov 3, 2015 | Publications
Abstract Over the past 1.5 decades, numerous stem cell trials have been performed in patients with cardiovascular disease. Although encouraging outcome signals have been reported, these have been small, leading to uncertainty as to whether they will translate into…
Oct 13, 2015 | Publications
Abstract Aims: This article describes an ongoing study investigating the safety and efficacy of ischemia-tolerant mesenchymal stem cell (MSC) therapy in patients with nonischemic heart failure and dysfunctional viable myocardium without scarring. This study will…
Sep 1, 2015 | Publications
Over the past 1.5 decades, numerous stem cell trials have been performed in patients with cardiovascular disease. Although encouraging outcome signals have been reported, these have been small, leading to uncertainty as to whether they will translate into significantly improved outcomes. A reassessment of the rationale for the use of stem cells in cardiovascular disease is therefore timely.
Combined Transplantation of Human Neuronal and Mesenchymal Stem Cells following Spinal Cord Injury
Mar 2, 2013 | Publications
Abstract Transplantation of human fetal neural stem cells (hNSCs) previously demonstrated significant functional recovery after spinal cord contusion in rats. Other studies indicated that human mesenchymal stem cells (hMSCs) can home to areas of damage and cross the…
Mar 1, 2013 | Publications
Abstract Object. The multipotency of neural stem cells (NSCs) can be assessed in vitro by detection of stage-specific markers in response to a suitable differentiation signal. This test is frequently used because it is fast and affordable. However, it is not clear how…
Jan 7, 2013 | Publications
Abstract Introduction A feature which makes stem cells promising candidates for cell therapy is their ability to migrate effectively into damaged or diseased tissues. Recent reports demonstrated the increased motility of human mesenchymal stem cells (hMSC) grown under…
Oct 16, 2012 | Publications
Abstract Background context Spinal cord injury can lead to severe functional impairments secondary to axonal damage, neuronal loss, and demyelination. The injured spinal cord has limited regrowth of damaged axons. Treatment remains controversial, given inconsistent…